Transcriptomics,Genomics

Dataset Information

300

Stretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells


ABSTRACT: T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.

ORGANISM(S): Musculus  

SUBMITTER: Vittorio Sartorelli   John J O'Shea  Yasuko Furumoto  Francis Collins  Kan Jiang  Rahul Roychoudhuri  Yuka Kanno  Nicholas P Restifo  Golnaz Vahedi 

PROVIDER: E-GEOD-60482 | ArrayExpress | 2015-02-18

SECONDARY ACCESSION(S): GSE60482SRP045570PRJNA258386

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Enhancers regulate spatiotemporal gene expression and impart cell-specific transcriptional outputs that drive cell identity. Super-enhancers (SEs), also known as stretch-enhancers, are a subset of enhancers especially important for genes associated with cell identity and genetic risk of disease. CD4(+) T cells are critical for host defence and autoimmunity. Here we analysed maps of mouse T-cell SEs as a non-biased means of identifying key regulatory nodes involved in cell specification. We found  ...[more]

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