Transcriptomics

Dataset Information

7

Genome-wide DNA methylation analysis of lung carcinoma : Gene expression data


ABSTRACT: Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. Experimental Design Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was performed on 12 normal lung tissues and 124 tumors including 83 adenocarcinomas, 23 squamous cell carcinomas (SqCC), one adenosquamous cancer, five large cell carcinomas, nine large cell neuroendocrine carcinomas (LCNEC), and three small cell carcinomas (SCLC). Complimentary gene expression analyses was performed on 117 of the 124 tumors using Illumina HT12 V4 arrays (reported here). Gene expression profiling of 117 lung carcinomas using Illumina HT-12 V4 microarrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Johan Staaf  

PROVIDER: E-GEOD-60644 | ArrayExpress | 2014-10-05

SECONDARY ACCESSION(S): GSE60644PRJNA259181

REPOSITORIES: GEO, ArrayExpress

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Publications

Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome.

Karlsson Anna A   Jönsson Mats M   Lauss Martin M   Brunnström Hans H   Jönsson Per P   Borg Åke Å   Jönsson Göran G   Ringnér Markus M   Planck Maria M   Staaf Johan J  

Clinical cancer research : an official journal of the American Association for Cancer Research 20141002 23


Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer remains unclear.Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was performed on 12 normal lung tissues and 124 tumors, including 83 adenocarcinomas, 23 squamous cell carcinomas (SqCC), 1  ...[more]

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