Transcriptomics

Dataset Information

4

Chronic ethanol exposure results in time and brain-region dependent changes in gene coexpression networks.


ABSTRACT: We examined global gene expression profiles in amygdala (AMY), nucleus accumbens (NAC), prefrontal cortex (PFC) and Liver of male C57BL/6J mice exposed to 4 cycles of chronic intermittent ethanol (CIE) vapor. Animals were sacrificed at 0, 8, and 120 hr following the last ethanol exposure. Mice were exposed to 4 cycles of intermittent vapor [4 days of 16 hours vapor/ 8 hours air] with a week between each cycle. Before entry into the vapor chambers, animals were injected with pyrazole (1 mMol/kg) and either ethanol (1.6 g/kg) or saline (controls). Animals were sacrificed at 0, 8, and 120 hr following the last ethanol exposure. The liver 0 hr control group contained 7 animals. Otherwise there were 8 animals per group (treated, control) at each time point.

ORGANISM(S): Mus musculus  

SUBMITTER: Elizabeth Osterndorff-Kahanek  

PROVIDER: E-GEOD-60676 | ArrayExpress | 2015-05-26

SECONDARY ACCESSION(S): GSE60676PRJNA259322

REPOSITORIES: GEO, ArrayExpress

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Publications

Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks.

Osterndorff-Kahanek Elizabeth A EA   Becker Howard C HC   Lopez Marcelo F MF   Farris Sean P SP   Tiwari Gayatri R GR   Nunez Yury O YO   Harris R Adron RA   Mayfield R Dayne RD  

PloS one 20150324 3


Repeated ethanol exposure and withdrawal in mice increases voluntary drinking and represents an animal model of physical dependence. We examined time- and brain region-dependent changes in gene coexpression networks in amygdala (AMY), nucleus accumbens (NAC), prefrontal cortex (PFC), and liver after four weekly cycles of chronic intermittent ethanol (CIE) vapor exposure in C57BL/6J mice. Microarrays were used to compare gene expression profiles at 0-, 8-, and 120-hours following the last ethanol  ...[more]

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