Dataset Information


Disrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease

ABSTRACT: Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification that inhibits AR transactivation function.

ORGANISM(S): Mus musculus  

SUBMITTER: Andrew P Lieberman   Richard C McEachin 

PROVIDER: E-GEOD-60691 | ArrayExpress | 2015-12-21



altmetric image


Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.

Chua Jason P JP   Reddy Satya L SL   Yu Zhigang Z   Giorgetti Elisa E   Montie Heather L HL   Mukherjee Sarmistha S   Higgins Jake J   McEachin Richard C RC   Robins Diane M DM   Merry Diane E DE   Iñiguez-Lluhí Jorge A JA   Lieberman Andrew P AP  

The Journal of clinical investigation 20150120 2

Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transcriptional function and exhibits ligand-dependent proteotoxicity, features that have both been implicated in SBMA; however, the extent to which altered AR transcriptional function contributes to pathogenesis remains controversial. Here, we sought to dissociate effects of diminished AR function from p  ...[more]

Similar Datasets

2014-08-23 | E-GEOD-50383 | ArrayExpress
2014-03-20 | E-GEOD-51975 | ArrayExpress
2013-08-01 | E-GEOD-48230 | ArrayExpress
2013-09-12 | E-GEOD-48364 | ArrayExpress
2011-03-01 | GSE26246 | GEO
| GSE65538 | GEO
2015-04-27 | E-GEOD-65850 | ArrayExpress
2015-01-01 | E-GEOD-61250 | ArrayExpress
2015-12-11 | E-GEOD-68915 | ArrayExpress
2015-10-28 | E-GEOD-66145 | ArrayExpress