Transcriptomics

Dataset Information

308

Disrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease


ABSTRACT: Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification that inhibits AR transactivation function.

ORGANISM(S): Mus musculus  

SUBMITTER: Andrew P Lieberman   Richard C McEachin 

PROVIDER: E-GEOD-60691 | ArrayExpress | 2015-12-21

SECONDARY ACCESSION(S): SRP045727GSE60691PRJNA259286

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.

Chua Jason P JP   Reddy Satya L SL   Yu Zhigang Z   Giorgetti Elisa E   Montie Heather L HL   Mukherjee Sarmistha S   Higgins Jake J   McEachin Richard C RC   Robins Diane M DM   Merry Diane E DE   Iñiguez-Lluhí Jorge A JA   Lieberman Andrew P AP  

The Journal of clinical investigation 20150120 2


Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transcriptional function and exhibits ligand-dependent proteotoxicity, features that have both been implicated in SBMA; however, the extent to which altered AR transcriptional function contributes to pathogenesis remains controversial. Here, we sought to dissociate effects of diminished AR function from p  ...[more]

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