Dataset Information


Gene expression alteration in chondrocyte by HES1 overexpression

ABSTRACT: To investigate target molecules of HES1, we transduced GFP or HES1 into mouse chondrocyte cell line ATDC5, and performed the microarray analysis. HES1 overexpression increased inflammation-related genes including Il6 and Il1rl1. We established stable ATDC5 cells overexpressing GFP or HES1 by lentiviral transduction. We harvested mRNA from these cells, and performed microarray analysis.

ORGANISM(S): Mus musculus  

SUBMITTER: Taku Saito   Shurei Sugita 

PROVIDER: E-GEOD-60737 | ArrayExpress | 2015-03-02



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Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.

Sugita Shurei S   Hosaka Yoko Y   Okada Keita K   Mori Daisuke D   Yano Fumiko F   Kobayashi Hiroshi H   Taniguchi Yuki Y   Mori Yoshifumi Y   Okuma Tomotake T   Chang Song Ho SH   Kawata Manabu M   Taketomi Shuji S   Chikuda Hirotaka H   Akiyama Haruhiko H   Kageyama Ryoichiro R   Chung Ung-Il UI   Tanaka Sakae S   Kawaguchi Hiroshi H   Ohba Shinsuke S   Saito Taku T  

Proceedings of the National Academy of Sciences of the United States of America 20150302 10

Notch signaling modulates skeletal formation and pathogenesis of osteoarthritis (OA) through induction of catabolic factors. Here we examined roles of Hes1, a transcription factor and important target of Notch signaling, in these processes. SRY-box containing gene 9 (Sox9)-Cre mice were mated with Hes1(fl/fl) mice to generate tissue-specific deletion of Hes1 from chondroprogenitor cells; this deletion caused no obvious abnormality in the perinatal period. Notably, OA development was suppressed w  ...[more]

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