Dataset Information


Normal mouse skin lacking Hras

ABSTRACT: Oncogenic activating mutations in Ras genes are among the most common drivers of human disease. Treating mouse skin with the chemical carcinogen DMBA induces a characteristic mutation in Hras at codon 61. To understand how skin responds to a constitutive lack of Hras, we generated a cohort of Hras knockout mice. A backcross was generated using male Mus spretus and female FVB/N Hras-/- mice; female F1 hybrids were mated with male FVB/N Hras -/- or Hras -/+ mice to generate a backcross population. This series contains mice that were Hras -/-. Mice were aged to 8 weeks and a tail skin sample was snap frozen.

ORGANISM(S): Mus musculus  

SUBMITTER: David A Quigley  David Quigley   Allan Balmain    

PROVIDER: E-GEOD-60769 | ArrayExpress | 2015-03-01



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