Dataset Information


Transcription profiling of mouse wildtype lungs vs. lung hypomorphic for nmyc

ABSTRACT: comparison of expression of wildtype lungs and lungs with hypomorphic expression of nmyc. the lungs were pooled from several biological samples. The hypomorphoic mutant was orignally published in Moens CB et al [PMID: 1577267]. this is part of a larger collection of data comparing nmyc misexpression in the lung (gain of fucntion) and protein expression in the hypomorphic lungs. Experiment Overall Design: samples from pooled lungs were analyzed.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Brian Joseph Cox  

PROVIDER: E-GEOD-6079 | ArrayExpress | 2008-06-14



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Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes.

Cox Brian B   Kislinger Thomas T   Wigle Dennis A DA   Kannan Anitha A   Brown Kevin K   Okubo Tadashi T   Hogan Brigid B   Jurisica Igor I   Frey Brendan B   Rossant Janet J   Emili Andrew A  

Molecular Systems Biology 20070508

Although microarray analysis has provided information regarding the dynamics of gene expression during development of the mouse lung, no extensive correlations have been made to the levels of corresponding protein products. Here, we present a global survey of protein expression during mouse lung organogenesis from embryonic day E13.5 until adulthood using gel-free two-dimensional liquid chromatography coupled to shotgun tandem mass spectrometry (MudPIT). Mathematical modeling of the proteomic pr  ...[more]

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