Transcriptomics

Dataset Information

31

Transcription profiling of rat mammary tumors with varying invasive phenotyes


ABSTRACT: We used microarrays to identify genes implicated in breast cancer progression Experiment Overall Design: By serially transplanting initial carcinogen induced rat mammary tumors (PR for primary tumor) through five generations of syngeneic hosts, we generated a series of tumors (T1 through T5) with varying invasive and metastatic phenoytpes

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Penelope Lyn Miron   

PROVIDER: E-GEOD-6093 | ArrayExpress| 2012-03-27

SECONDARY ACCESSION(S): GSE6093PRJNA97651

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Serial transplantation of NMU-induced rat mammary tumors: a model of human breast cancer progression.

Chan Maren M MM   Lu Xin X   Merchant Faisal M FM   Iglehart James Dirk JD   Miron Penelope L PL  

International journal of cancer 20070801 3


Human breast cancer is a heterogeneous disease that appears to progress from an in situ tumor to invasive cancer. Little is known about the molecular events driving this progression. Although microarray technology has helped us understand the genetic heterogeneity of breast cancer, its application to studying the transition from in situ to invasive disease is limited by the inability to follow the progression of a single patient's tumor. We previously used rat specific microarrays to show that N  ...[more]

Similar Datasets

2007-04-20 | GSE6093 | GEO
2011-02-01 | GSE24917 | GEO
2011-10-31 | E-GEOD-24917 | ArrayExpress
2015-05-02 | E-GEOD-40997 | ArrayExpress
2009-12-09 | GSE9495 | GEO
2014-05-02 | E-GEOD-16672 | ArrayExpress
2014-05-02 | E-GEOD-9495 | ArrayExpress
| GSE14458 | GEO
2009-07-10 | GSE16672 | GEO
2014-05-01 | E-GEOD-14458 | ArrayExpress