Transcriptomics

Dataset Information

35

Molecular portraits of human breast tumors


ABSTRACT: Set of 65 surgical specimens of human breast tumors from 42 different individuals, using complementary DNA microarrays representing 8,102 human genes. Gene expression variation patterns within this set provided a distinctive molecular portrait of each tumor. Twenty of the tumors were sampled twice, before and after a 16-week course of doxorubicin chemotherapy, and two tumors were paired with a lymph node metastasis from the same patient. Gene expression patterns in two tumor samples from the same individual were almost always more similar to each other than either was to any other sample. This study is described more fully in Perou CM et al.(2000) Nature 406:747-52

ORGANISM(S): Homo sapiens  

SUBMITTER: T Sorlie  Stanford Microarray Database   C Williams   O Fluge   M B Eisen   A L Borresen-Dale   L A Akslen   S S Jeffrey   D Botstein   H Johnsen   M van de Rijn   P O Brown   C M Perou   A Pergamenschikov   P E Lonning   C A Rees   S X Zhu   J R Pollack   D T Ross    

PROVIDER: E-GEOD-61 | ArrayExpress| 2012-03-27

SECONDARY ACCESSION(S): GSE61PRJNA85417

REPOSITORIES: GEO, ArrayExpress

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Publications


Human breast tumours are diverse in their natural history and in their responsiveness to treatments. Variation in transcriptional programs accounts for much of the biological diversity of human cells and tumours. In each cell, signal transduction and regulatory systems transduce information from the cell's identity to its environmental status, thereby controlling the level of expression of every gene in the genome. Here we have characterized variation in gene expression patterns in a set of 65 s  ...[more]

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