Dataset Information


Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance and response in castration-resistant prostate cancer

ABSTRACT: aCGH experiment on cell-free DNA collected from the plasma of patients with castration-resistant prostate cancer. No replicates. castration-resistant prostate cancer vs male reference DNA

ORGANISM(S): Homo sapiens  

SUBMITTER: S V Volik   A W Wyatt  Shawn Anderson  C C Collins  S A Anderson 

PROVIDER: E-GEOD-61134 | ArrayExpress | 2015-03-09



altmetric image


Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer.

Azad Arun A AA   Volik Stanislav V SV   Wyatt Alexander W AW   Haegert Anne A   Le Bihan Stephane S   Bell Robert H RH   Anderson Shawn A SA   McConeghy Brian B   Shukin Robert R   Bazov Jenny J   Youngren Jack J   Paris Pamela P   Thomas George G   Small Eric J EJ   Wang Yuzhuo Y   Gleave Martin E ME   Collins Colin C CC   Chi Kim N KN  

Clinical cancer research : an official journal of the American Association for Cancer Research 20150223 10

Although novel agents targeting the androgen-androgen receptor (AR) axis have altered the treatment paradigm of metastatic castration-resistant prostate cancer (mCRPC), development of therapeutic resistance is inevitable. In this study, we examined whether AR gene aberrations detectable in circulating cell-free DNA (cfDNA) are associated with resistance to abiraterone acetate and enzalutamide in mCRPC patients.Plasma was collected from 62 mCRPC patients ceasing abiraterone acetate (n = 29), enza  ...[more]

Similar Datasets

2013-01-12 | E-GEOD-41188 | ArrayExpress
2015-01-05 | E-GEOD-59985 | ArrayExpress
2011-12-22 | E-GEOD-34649 | ArrayExpress
2013-04-02 | E-GEOD-45705 | ArrayExpress
| GSE69331 | GEO
2013-04-20 | E-GEOD-46218 | ArrayExpress
2010-06-23 | E-GEOD-13332 | ArrayExpress
| GSE100239 | GEO
2010-05-19 | GSE21887 | GEO
2010-05-22 | E-GEOD-18259 | ArrayExpress