Transcriptomics

Dataset Information

3

Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance and response in castration-resistant prostate cancer


ABSTRACT: aCGH experiment on cell-free DNA collected from the plasma of patients with castration-resistant prostate cancer. No replicates. castration-resistant prostate cancer vs male reference DNA

ORGANISM(S): Homo sapiens  

SUBMITTER: S V Volik   A W Wyatt  Shawn Anderson  C C Collins  S A Anderson 

PROVIDER: E-GEOD-61134 | ArrayExpress | 2015-03-09

SECONDARY ACCESSION(S): GSE61134PRJNA260306

REPOSITORIES: GEO, ArrayExpress

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Publications

Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer.

Azad Arun A AA   Volik Stanislav V SV   Wyatt Alexander W AW   Haegert Anne A   Le Bihan Stephane S   Bell Robert H RH   Anderson Shawn A SA   McConeghy Brian B   Shukin Robert R   Bazov Jenny J   Youngren Jack J   Paris Pamela P   Thomas George G   Small Eric J EJ   Wang Yuzhuo Y   Gleave Martin E ME   Collins Colin C CC   Chi Kim N KN  

Clinical cancer research : an official journal of the American Association for Cancer Research 20150223 10


Although novel agents targeting the androgen-androgen receptor (AR) axis have altered the treatment paradigm of metastatic castration-resistant prostate cancer (mCRPC), development of therapeutic resistance is inevitable. In this study, we examined whether AR gene aberrations detectable in circulating cell-free DNA (cfDNA) are associated with resistance to abiraterone acetate and enzalutamide in mCRPC patients.Plasma was collected from 62 mCRPC patients ceasing abiraterone acetate (n = 29), enza  ...[more]

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