Transcriptomics,Genomics,Multiomics

Dataset Information

63

B-Catenin Mediates the Development of Behavioral Resilience


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Li Shen   

PROVIDER: E-GEOD-61296 | ArrayExpress | 2014-11-28

SECONDARY ACCESSION(S): GSE61296PRJNA260680

REPOSITORIES: GEO, ArrayExpress

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Publications


β-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice β-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide β-catenin enrichment mapping, we identify Dicer1-important in small RNA (for example, microRN  ...[more]

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