Transcriptomics

Dataset Information

65

DNA methylation screening of small bowel adenocarcinoma


ABSTRACT: Illumina Infinium 450k screening of normal and tumour tissue in a retrospective 28 sample cohort of small bowel adenocarcinoma patients. Average signal and beta values normalised to internal Illumina controls. Comparing DNA methylation differences in a matched normal tumour cohort of 28 small bowel adenocarcinoma patients.

ORGANISM(S): Homo sapiens  

SUBMITTER: Manuel Salto-Tellez   Muhammad A Alvi  Muhammad Abdullah Alvi 

PROVIDER: E-GEOD-61467 | ArrayExpress | 2015-09-03

SECONDARY ACCESSION(S): GSE61467PRJNA261243

REPOSITORIES: GEO, ArrayExpress

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Publications


Small bowel accounts for only 0.5% of cancer cases in the US but incidence rates have been rising at 2.4% per year over the past decade. One-third of these are adenocarcinomas but little is known about their molecular pathology and no molecular markers are available for clinical use. Using a retrospective 28 patient matched normal-tumor cohort, next-generation sequencing, gene expression arrays and CpG methylation arrays were used for molecular profiling. Next-generation sequencing identified no  ...[more]

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