Dataset Information


MiRNA profiling in high-grade serous ovarian carcinoma

ABSTRACT: In this study, we performed miRNA profiles analysis of high-grade serous ovarian carcinoma compared to normal fallopian tube fimbria using microarray (Exiqon, Denmark) to evaluate their potential role in the pathogenesis of uterine leiomyoma. miRNA profiling analysis of the 10 samples including 5 high-grade serous ovarian carcinomas and 5 normal fallopian tube fimbria.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ruifen Dong  Zhaojian Liu   Beihua Kong    

PROVIDER: E-GEOD-61485 | ArrayExpress | 2014-11-28



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miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma.

Dong Ruifen R   Liu Xiaolin X   Zhang Qing Q   Jiang Zhijun Z   Li Yingwei Y   Wei Yuyan Y   Li Yinuo Y   Yang Qifeng Q   Liu Jinsong J   Wei Jian-Jun JJ   Shao Changshun C   Liu Zhaojian Z   Kong Beihua B  

Oncotarget 20141101 21

High-grade serous ovarian carcinoma (HGSOC), the most common and aggressive subtype of epithelial ovarian cancer, is characterized by TP53 mutations and genetic instability. Using miRNA profiling analysis, we found that miR-145, a p53 regulated miRNA, was frequently down-regulated in HGSOC. miR-145 down-regulation was further validated in a large cohort of HGSOCs by qPCR. Overexpression of miR-145 in ovarian cancer cells significantly suppressed proliferation, migration and invasion in vitro and  ...[more]

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