Dataset Information


Epigenetic signature of birth-weight discordance in Danish twins

ABSTRACT: Epigenetic profiling of birth-weight discordant twins using Illumina's 450K Human DNA methylation BeadChip Comparing DNA methylation difference in birth-weight discordant twin pairs

ORGANISM(S): Homo sapiens  

SUBMITTER: Lene Christiansen   Qihua Tan  Morten Frost 

PROVIDER: E-GEOD-61496 | ArrayExpress | 2014-12-15



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Epigenetic signature of birth weight discordance in adult twins.

Tan Qihua Q   Frost Morten M   Heijmans Bastiaan T BT   von Bornemann Hjelmborg Jacob J   Tobi Elmar W EW   Christensen Kaare K   Christiansen Lene L  

BMC genomics 20141204

BACKGROUND: A low birth weight has been extensively related to poor adult health outcomes. Birth weight can be seen as a proxy for environmental conditions during prenatal development. Identical twin pairs discordant for birth weight provide an extraordinary model for investigating the association between birth weight and adult life health while controlling for not only genetics but also postnatal rearing environment. We performed an epigenome-wide profiling on blood samples from 150 pairs of ad  ...[more]

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