Transcriptomics

Dataset Information

5

Expression data from OVCAR-3 cells overexpressing histone H1.3


ABSTRACT: Ovarian cancer is a deadly gynecological malignancy for which novel biomarkers and therapeutic targets are imperative for improving survival. To investigate the role of histone H1 in ovarian cancer cells, we overexpress a histone H1 variant, H1.3, in the OVCAR-3 epithelial ovarian cancer cell line. RNA was extracted from OV-3/H1.3(H) cells (OVCAR-3 with overexpression of H1.3) and control cells of OVCAR-3 transfected with vectors without H1.3. The microarray chip used was human Affymetrix ST1.0 array. Gene expression changes caused by overexpression of H1.3 in OVCAR-3 cells were identified. Affymetrix Human Exon 1.0 ST array was used to identify the changes in transcriptome of OVCAR-3 caused by overexpression of H1.3

ORGANISM(S): Homo sapiens  

SUBMITTER: Chenyi Pan   Yuhong Fan  Yunzhe Zhang  Weijia Zhang  Magdalena Medrzycki 

PROVIDER: E-GEOD-61692 | ArrayExpress | 2014-10-31

SECONDARY ACCESSION(S): GSE61692PRJNA261852

REPOSITORIES: GEO, ArrayExpress

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