Dataset Information


Transcription profiling of mouse mucosal mast cell in vitro differentiation

ABSTRACT: The aim of the study was to find novel genes highly upregulated in mouse mucosal mast cells. To carry it out, differentiating progenitor cells were isolated on day4 of culturing and compared to mature mucosal mast cells obtained by day20. Experiment Overall Design: The experiment was carried out on two microarrays. Array2 is a biological and technical replicate (dye-swap) of array1. In both cases, 3-3 samples were pooled, but of different origin.

ORGANISM(S): Mus musculus  

SUBMITTER: Zoltan Wiener  

PROVIDER: E-GEOD-6192 | ArrayExpress | 2008-06-14



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HtrA1 is a novel mast cell serine protease of mice and men.

Gilicze Anna A   Kohalmi Barbara B   Pocza Peter P   Keszei Marton M   Jaeger Judit J   Gorbe Eva E   Papp Zoltan Z   Toth Sara S   Falus Andras A   Wiener Zoltan Z  

Molecular immunology 20070212 11

Mast cells are rich sources of proteases, such as tryptases and chymases that control many physiological and pathological processes, for example vascular permeability, smooth muscle cell proliferation or extracellular matrix remodeling. Murine mucosal mast cells mature under the influence of TGF-beta and play a role in asthmatic and anti-helminthic immune responses. In an attempt to identify novel genes that are highly upregulated during mucosal mast cell differentiation, we detected HtrA1 prote  ...[more]

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