Ontology highlight
ABSTRACT:
INSTRUMENT(S): 418 [Affymetrix]
ORGANISM(S): Mus musculus
SUBMITTER: YULIN LI
PROVIDER: E-GEOD-6193 | ArrayExpress | 2008-06-14
SECONDARY ACCESSION(S): GSE6193PRJNA97547
REPOSITORIES: GEO, ArrayExpress
Zhang Wei W Feng Daorong D Li Yulin Y Iida Kaori K McGrath Barbara B Cavener Douglas R DR
Cell metabolism 20061201 6
Mutations in PERK (EIF2AK3) result in permanent neonatal diabetes as well as several other anomalies that underlie the human Wolcott-Rallison syndrome, and these anomalies are mirrored in Perk knockout mice. To identify the cause of diabetes in PERK-deficient mice, we generated a series of tissue- and cell-specific knockouts of the Perk gene and performed a developmental analysis of the progression to overt diabetes. We discovered that PERK is specifically required in the insulin-secreting beta ...[more]