Transcriptomics

Dataset Information

3

Transcription profiling of mouse PERK knockouts vs. wikd type


ABSTRACT: to study the proliferation of PERK knockout mice islets. The major changes are the proliferation genes Experiment Overall Design: 2days after birth, Experiment Overall Design: Collagenase P digestion Experiment Overall Design: cRNA label with Ambion kit Experiment Overall Design: Hybridization with Affymetrix mouse 430A chip

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: YULIN LI 

PROVIDER: E-GEOD-6193 | ArrayExpress | 2008-06-14

SECONDARY ACCESSION(S): GSE6193PRJNA97547

REPOSITORIES: GEO, ArrayExpress

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Publications

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

Zhang Wei W   Feng Daorong D   Li Yulin Y   Iida Kaori K   McGrath Barbara B   Cavener Douglas R DR  

Cell metabolism 20061201 6


Mutations in PERK (EIF2AK3) result in permanent neonatal diabetes as well as several other anomalies that underlie the human Wolcott-Rallison syndrome, and these anomalies are mirrored in Perk knockout mice. To identify the cause of diabetes in PERK-deficient mice, we generated a series of tissue- and cell-specific knockouts of the Perk gene and performed a developmental analysis of the progression to overt diabetes. We discovered that PERK is specifically required in the insulin-secreting beta  ...[more]

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