Transcriptomics

Dataset Information

5

Oncogenic potential of RAS isoforms in melanocytes


ABSTRACT: We compared the transformation efficiencies of mutant NRAS and KRAS in immortal, non-transformed Ink4a/Arf-deficient melanocytes. NRAS mutation leads to increased cellular proliferation and is potently tumorigenic. In contrast, KRAS mutation does not enhance melanocyte proliferation and is only weakly tumorigenic on its own. While both NRAS and KRAS activate MAPK signaling, only NRAS enhances MYC activity in these cells. Our data suggests that the activity of specific RAS isoforms is context dependent and provides a possible explanation for the prevalence of NRAS mutations in melanoma.In addition, understanding this mechanism will have important implications for cancer therapies targeting RAS pathways. Keywords: RAS isoforms Common Reference

ORGANISM(S): Mus musculus  

SUBMITTER: Sheri Holmen   Karl Dykema 

PROVIDER: E-GEOD-6194 | ArrayExpress | 2010-06-10

SECONDARY ACCESSION(S): GSE6194PRJNA100677

REPOSITORIES: GEO, ArrayExpress

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