Transcriptomics

Dataset Information

50

The global transcriptional profile of Mycobacterium tuberculosis during human macrophages infection


ABSTRACT: During lung infection Mycobacterium tuberculosis (Mtb) resides in macrophages and subverts the bactericidal mechanisms of these professional phagocytes. In this work we have analyzed by DNA microarray technique the global transcription profile of Mtb infecting primary human macrophages in order to identify putative bacterial pathogenic factors that can be relevant for the intracellular survival of Mtb. Keywords: time course We compared the global gene expression of the H37Rv strain of Mtb after 4 hours and 24 hours of infection of human macrophage-like THP-1 cells with the gene expression profile of the strain growing exponentially in broth cultures.

ORGANISM(S): Mycobacterium tuberculosis  

SUBMITTER: Saleena S Ghanny  Virginie M Aris   Issar Smith   Virginie Marie Aris   Patricia Fontan   Patricia Soteropoulos    

PROVIDER: E-GEOD-6209 | ArrayExpress| 2014-05-02

SECONDARY ACCESSION(S): GSE6209PRJNA104989

REPOSITORIES: GEO, ArrayExpress

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Publications

Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response.

Fontán Patricia A PA   Aris Virginie V   Alvarez María E ME   Ghanny Saleena S   Cheng Jeff J   Soteropoulos Patricia P   Trevani Analia A   Pine Richard R   Smith Issar I  

The Journal of infectious diseases 20080901 6


Mycobacterium tuberculosis survives in macrophages and usually subverts the bactericidal mechanisms of these phagocytes. The understanding of this host-pathogen interaction is relevant for the development of new treatments for tuberculosis. The adaptation of M. tuberculosis to intracellular life depends on its ability to regulate the expression of its genes. Sigma factors are important bacterial transcription activators that bind to the RNA polymerase and give it promoter specificity. Sigma fact  ...[more]

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