Dataset Information


Transcription profiling of rats with rare arterial and renal phenotypes

ABSTRACT: The Brown Norway (BN) strain of rat is an inbred normotensive strain. BN rats of both sexes present some interesting pathophysiological phenotypes involving arteries and the kidneys. These include internal elastic lamina (IEL) ruptures in the abdominal aorta and iliac arteries, a deficit in aortic elastin content, a persistent ductus arteriosus, hydronephrosis and hematuria. Spontaneous rupture of the internal elastic lamina occurs in various arteries during growth and aging, in different rat strains, both normotensive and hypertensive. Most strains present such ruptures in their caudal and renal arteries, although to different extents (Osborne-Pellegrin 1985; Coutard and Osborne-Pellegrin 1991). However, the BN strain is the only rat strain to spontaneously develop numerous IEL ruptures in the abdominal aorta and iliac arteries (Osborne-Pellegrin et al., 1989; Behmoaras J et al., 2005). In this respect, it is exceptional. In this study samples of abdominal aortae of BN- and LOU-rats (here as control) were compared Experiment Overall Design: 10 chips were analyzed. They represent 2 groups of 5 replicates each. Experiment Overall Design: The 2 groups are 2 different rat strains: BN and LOU. Experiment Overall Design: Samples were prepared only from abdominal aortae (tissue).

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Oliver Hummel  

PROVIDER: E-GEOD-6215 | ArrayExpress | 2008-06-14



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Quantitative genetic basis of arterial phenotypes in the Brown Norway rat.

Kota Lalitha L   Osborne-Pellegrin Mary M   Schulz Herbert H   Behmoaras Jacques J   Coutard Michèle M   Gong Maolian M   Hübner Norbert N  

Physiological genomics 20070313 1

The Brown Norway (BN) rat presents several genetically determined arterial phenotypes of interest, i.e., ruptures of the internal elastic lamina (RIEL) in the abdominal aorta (AA), iliac (IAs), and renal arteries, aortic elastin deficit and higher frequency of persistent ductus arteriosus (PDA) than other strains. We investigated the genetic basis of these phenotypes. We established a backcross between BN and the LOU reference strain and performed a genome-wide scan on 104 males and 105 females  ...[more]

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