Transcriptomics

Dataset Information

0

IL6-STAT3 downstream targets in MCF10A/MCF10A.ErbB2* cells


ABSTRACT: Overexpression in IL6 in MCF10A vs. WT, MCF10A.ErbB2* with/without shRNA targeting STAT3 Overexpression in IL6 in MCF10A vs. WT, MCF10A.ErbB* with/without shSTAT3, duplicates, two STAT3 shRNAs

ORGANISM(S): Homo sapiens  

SUBMITTER: Jose M Silva   Jiyang Yu  Andrea Califano  Ruth Rodriguez-Barrueco 

PROVIDER: E-GEOD-62235 | ArrayExpress | 2015-09-03

SECONDARY ACCESSION(S): GSE62235PRJNA263584

REPOSITORIES: GEO, ArrayExpress

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Publications


HER2-positive (HER2(+)) breast adenocarcinomas are a heterogeneous group in which hormone receptor (HR) status influences therapeutic decisions and patient outcome. By combining genome-wide RNAi screens with regulatory network analysis, we identified STAT3 as a critically activated master regulator of HR(-)/HER2(+) tumors, eliciting tumor dependency in these cells. Mechanistically, HR(-)/HER2(+) cells secrete high levels of the interleukin-6 (IL-6) cytokine, inducing the activation of STAT3, whi  ...[more]

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