Transcriptomics

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Gene expression profiling of ErbB2-engineered MCF10A and WT cells


ABSTRACT: Gene expression profiling of ErbB2-engineered MCF10A and WT cells in 2D and 3D culture Gene expression profiling of ErbB2-engineered MCF10A and WT cells, 2D and 3D culture, 5 or 6 replicates

ORGANISM(S): Homo sapiens  

SUBMITTER: Jose M Silva   Jiyang Yu  Andrea Califano  Ruth Rodriguez-Barrueco 

PROVIDER: E-GEOD-62250 | ArrayExpress | 2015-09-03

SECONDARY ACCESSION(S): GSE62250PRJNA263585

REPOSITORIES: GEO, ArrayExpress

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Publications


HER2-positive (HER2(+)) breast adenocarcinomas are a heterogeneous group in which hormone receptor (HR) status influences therapeutic decisions and patient outcome. By combining genome-wide RNAi screens with regulatory network analysis, we identified STAT3 as a critically activated master regulator of HR(-)/HER2(+) tumors, eliciting tumor dependency in these cells. Mechanistically, HR(-)/HER2(+) cells secrete high levels of the interleukin-6 (IL-6) cytokine, inducing the activation of STAT3, whi  ...[more]

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