Transcriptomics

Dataset Information

41

Identification of pathogenic microRNAs in Helicobacter pylori-associated gastric cancer


ABSTRACT: To identify dysregulated miRNA(s) upon infection with H. pylori during different pre-malignant and malignant stages of gastric cancer in a mouse model miRNA expression in pre-neoplastic and neoplastic lesions in murine stomachs induced by H. pylori and N-methyl-N-nitrosourea (MNU) after 12 months was profiled by miRNA expression array.

ORGANISM(S): Mus musculus  

SUBMITTER: William K Wu  Jing Shen    

PROVIDER: E-GEOD-62503 | ArrayExpress| 2015-03-06

SECONDARY ACCESSION(S): GSE62503PRJNA264303

REPOSITORIES: GEO, ArrayExpress

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Publications


Chromatin remodeling has emerged as a hallmark of gastric cancer, but the regulation of chromatin regulators other than genetic change is unknown. Helicobacter pylori causes epigenetic dysregulation to promote gastric carcinogenesis, but the roles and functions of microRNAs (miRNA) in this multistage cascade are not fully explored. In this study, miRNA expression in preneoplastic and neoplastic lesions in murine stomachs induced by H. pylori and N-methyl-N-nitrosourea (MNU) was profiled by miRNA  ...[more]

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