Dataset Information


Influence of neutrophils in tumor-supportive stromal cells gene expression in non-Hodgkin B-cell lymphoma

ABSTRACT: Tumor infiltrating neutrophils (TAN) have been shown to exert both pro- and anti-tumoral activities and their recruitment and polarization are triggered by tumor-derived signals. Resident mesenchymal stromal cells (MSC) could contribute to tumor-supportive cell niche and have been shown to display tumor-specific transcriptomic, phenotypic, and functional features compared to normal tissue. In our study, we investigate whether these two cell subsets establish a bidirectional crosstalk in the context of B-cell lymphoma. We used microarrays to explore how neutrophils could trigger the polarization of tumor-supportive stromal cells. Gene expression analysis were performed on stromal cells (MSC) derived from bone marrow (BM) or tonsil (Resto) of healthy donors. These BM-MSC (n=3) or Resto (n=3) were primed or not with neutrophils for 1 day to induce stromal modification.

ORGANISM(S): Homo sapiens  

SUBMITTER: Murielle Gregoire   Karin Tarte 

PROVIDER: E-GEOD-62782 | ArrayExpress | 2015-05-11



Similar Datasets

2014-03-01 | E-GEOD-44181 | ArrayExpress
2013-01-31 | E-GEOD-34973 | ArrayExpress
2018-10-25 | PXD003018 | Pride
2016-02-19 | E-GEOD-78047 | ArrayExpress
2012-10-21 | E-GEOD-39410 | ArrayExpress
2014-04-01 | E-GEOD-56362 | ArrayExpress
| PRJNA265108 | ENA
2011-10-23 | E-GEOD-24892 | ArrayExpress
2015-09-30 | E-MTAB-3795 | ArrayExpress
2015-03-26 | E-GEOD-59966 | ArrayExpress