Transcriptomics

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Influence of neutrophils in tumor-supportive stromal cells gene expression in non-Hodgkin B-cell lymphoma


ABSTRACT: Tumor infiltrating neutrophils (TAN) have been shown to exert both pro- and anti-tumoral activities and their recruitment and polarization are triggered by tumor-derived signals. Resident mesenchymal stromal cells (MSC) could contribute to tumor-supportive cell niche and have been shown to display tumor-specific transcriptomic, phenotypic, and functional features compared to normal tissue. In our study, we investigate whether these two cell subsets establish a bidirectional crosstalk in the context of B-cell lymphoma. We used microarrays to explore how neutrophils could trigger the polarization of tumor-supportive stromal cells. Gene expression analysis were performed on stromal cells (MSC) derived from bone marrow (BM) or tonsil (Resto) of healthy donors. These BM-MSC (n=3) or Resto (n=3) were primed or not with neutrophils for 1 day to induce stromal modification.

ORGANISM(S): Homo sapiens  

SUBMITTER: Murielle Gregoire   Karin Tarte 

PROVIDER: E-GEOD-62782 | ArrayExpress | 2015-05-11

SECONDARY ACCESSION(S): GSE62782PRJNA265108

REPOSITORIES: GEO, ArrayExpress

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