Transcriptomics

Dataset Information

32

Expression profiles of liver tissues from wild-type and AID transgenic mice exposed to thioacetamide hepatotoxicity


ABSTRACT: AID is an intrinsic DNA mutator enzyme and contributes to tumorigenesis through the accumulation of genetic aberrations. To examine whether mutagenesis induced by AID during inflammation-associated hepatocarcinogenesis depends on the transcriptional levels of the target genes, we performed the gene expression profiling of liver tissues from AID transgenic mice and wild-type mice with and without thioacetamide treatment. AID transgenic mice and wild-type mice were administered with thioacetamide in drinking water for 6 months, and the gene expression levels of their livers are compared.

ORGANISM(S): Mus musculus  

SUBMITTER: Hiroyuki Marusawa  Tomonori Matsumoto    

PROVIDER: E-GEOD-62878 | ArrayExpress| 2015-08-19

SECONDARY ACCESSION(S): GSE62878PRJNA265874

REPOSITORIES: GEO, ArrayExpress

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Publications

Hepatic inflammation facilitates transcription-associated mutagenesis via AID activity and enhances liver tumorigenesis.

Matsumoto Tomonori T   Shimizu Takahiro T   Nishijima Norihiro N   Ikeda Atsuyuki A   Eso Yuji Y   Matsumoto Yuko Y   Chiba Tsutomu T   Marusawa Hiroyuki H  

Carcinogenesis 20150512 8


Chronic inflammation triggers the aberrant expression of a DNA mutator enzyme, activation-induced cytidine deaminase (AID), and contributes to tumorigenesis through the accumulation of genetic aberrations. To gain further insight into the inflammation-mediated genotoxic events required for carcinogenesis, we examined the role of chronic inflammation in the emergence of genetic aberrations in the liver with constitutive AID expression. Treatment with thioacetamide (TAA) at low-dose concentrations  ...[more]

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