Transcriptomics

Dataset Information

30

Pituitary tumors contain a side population with 'tumor stem cell'-associated characteristics.


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Wouter Van Delm   

PROVIDER: E-GEOD-62960 | ArrayExpress| 2015-08-19

SECONDARY ACCESSION(S): GSE62960PRJNA266292

REPOSITORIES: GEO, ArrayExpress

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Publications


Pituitary adenomas cause significant endocrine and mass-related morbidity. Little is known about the mechanisms that underlie pituitary tumor pathogenesis. In the present study, we searched for a side population (SP) in pituitary tumors representing cells with high efflux capacity and potentially enriched for tumor stem cells (TSCs). Human pituitary adenomas contain a SP irrespective of hormonal phenotype. This adenoma SP, as well as the purified SP (pSP) that is depleted from endothelial and im  ...[more]

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