Genomics

Dataset Information

300

Dynamic epigenetic regulation by menin during pancreatic islet tumor formation


ABSTRACT: loss of Men1 in mouse pancreatic islet cells alters the epigenetic landscape of a subset of target genes. H3K4me3 ChIP-seq from either mouse pancreatic islets or mouse pancreatic islet tumors harvested at different stages.

ORGANISM(S): Mus musculus  

SUBMITTER: Hideo Watanabe   Wenchu Lin  Matthew Meyerson 

PROVIDER: E-GEOD-63020 | ArrayExpress | 2015-04-16

SECONDARY ACCESSION(S): SRP049559GSE63020PRJNA266443

REPOSITORIES: GEO, ArrayExpress, ENA

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Dynamic epigenetic regulation by menin during pancreatic islet tumor formation.

Lin Wenchu W   Watanabe Hideo H   Peng Shouyong S   Francis Joshua M JM   Kaplan Nathan N   Pedamallu Chandra Sekhar CS   Ramachandran Aruna A   Agoston Agoston A   Bass Adam J AJ   Meyerson Matthew M  

Molecular cancer research : MCR 20141223 4


The tumor suppressor gene MEN1 is frequently mutated in sporadic pancreatic neuroendocrine tumors (PanNET) and is responsible for the familial multiple endocrine neoplasia type 1 (MEN-1) cancer syndrome. Menin, the protein product of MEN1, associates with the histone methyltransferases (HMT) MLL1 (KMT2A) and MLL4 (KMT2B) to form menin-HMT complexes in both human and mouse model systems. To elucidate the role of methylation of histone H3 at lysine 4 (H3K4) mediated by menin-HMT complexes during P  ...[more]

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