Transcriptomics

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Single-cell transcriptome analysis of secretagogin mRNA expressing cells from the mouse hypothalamic paraventricular nucleus


ABSTRACT: The molecular mechanism regulating phasic corticotropin-releasing hormone (CRH) release from parvocellular neurons (PVN) remains poorly understood. Here, we find a cohort of parvocellular cells interspersed with magnocellular PVN neurons expressing secretagogin. Single-cell transcriptome analysis combined with protein interactome profiling identifies secretagogin neurons as a distinct CRH-releasing neuron population reliant on secretagogin’s Ca2+ sensor properties and protein interactions with the vesicular traffic and exocytosis release machineries to liberate this key hypothalamic releasing hormone. single cells from the PVN region juvenile (21-28 days) mice were dissected and subject to whole transcriptome analysis

ORGANISM(S): Mus musculus  

SUBMITTER: Sten Linnarsson   Roman Romonov 

PROVIDER: E-GEOD-63093 | ArrayExpress | 2014-11-20

SECONDARY ACCESSION(S): GSE63093SRP049615PRJNA266609

REPOSITORIES: GEO, ArrayExpress, ENA

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