Transcriptomics

Dataset Information

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MicroRNA expression signatures of imatinib-treated and non-treated gastrointestinal stromal tumors


ABSTRACT: We performed microRNA expression profiling in a series of fresh-frozen neoadjuvantly imatinib-treated and non-treated gastrointestinal stromal tumors (GIST), using a microarray approach. Significant differentially expressed microRNAs among imatinib-treated and non-treated groups were identified using SAM analysis. Agilent microarray platform with probes matching 903 human microRNAs was used to determine miRNA expression profiles in 34 GISTs (19 imatinib-treated and 15 non-treated). Re-analysis of GSE45901 for 17 imatinib-treated GISTs. To validate the microarray platform, the expression levels of selected microRNAs were evaluated using qRT-PCR.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jan Åhlen   Mehran Ghaderi  Stefano Caramuta  Pinar Akçakaya  Robert Bränström  Katarina Zeljic  Catharina Larsson  Pinar Akcakaya  Erik Berglund  Weng-Onn Lui  Anastasia Gangaev 

PROVIDER: E-GEOD-63159 | ArrayExpress | 2015-08-01

SECONDARY ACCESSION(S): GSE63159PRJNA266835

REPOSITORIES: GEO, ArrayExpress

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