Dataset Information


Transcription profiling of human MDA-MB-231 cells infeted with Flag-SR-IkBa vs. vector

ABSTRACT: We used human Affymetrix microarrays to identify the up- or down-regulated gene expressions from MDA-MB-231 cells infected with control vector or Flag-SR-IkBa Experiment Overall Design: The pattern of gene expression from MDA-MB-231 cells transduced with retroviruses were analysed by RNA extraction and hybridization on Affymetrix microarrays. From expression profiles, we identified NF-kB target genes, and uncovered a novel and specific role of a gene in osteolytic bone metastasis.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Bae Keun Park  

PROVIDER: E-GEOD-6324 | ArrayExpress | 2008-06-14



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NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF.

Park Bae Keun BK   Zhang Honglai H   Zeng Qinghua Q   Dai Jinlu J   Keller Evan T ET   Giordano Thomas T   Gu Keni K   Shah Veena V   Pei Lei L   Zarbo Richard J RJ   McCauley Laurie L   Shi Songtao S   Chen Shaoqiong S   Wang Cun-Yu CY  

Nature medicine 20061210 1

Advanced breast cancers frequently metastasize to bone, resulting in osteolytic lesions, yet the underlying mechanisms are poorly understood. Here we report that nuclear factor-kappaB (NF-kappaB) plays a crucial role in the osteolytic bone metastasis of breast cancer by stimulating osteoclastogenesis. Using an in vivo bone metastasis model, we found that constitutive NF-kappaB activity in breast cancer cells is crucial for the bone resorption characteristic of osteolytic bone metastasis. We iden  ...[more]

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