Transcriptomics

Dataset Information

0

Anti-inflammatory compounds in SCI


ABSTRACT: A screen of 5 anti-inflammatory compounds for their effects in explanted, cultured rat spinal cord slices. All injured (explanted) cords are cultured for 4 hrs.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Jonathan Z Pan  Rebecka Jornsten   Ronald Hart   Ronald P Hart    

PROVIDER: E-GEOD-633 | ArrayExpress | 2010-06-05

SECONDARY ACCESSION(S): GSE633PRJNA87541

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Screening anti-inflammatory compounds in injured spinal cord with microarrays: a comparison of bioinformatics analysis approaches.

Pan Jonathan Z JZ   Jörnsten Rebecka R   Hart Ronald P RP  

Physiological genomics 20040413 2


Inflammatory responses contribute to secondary tissue damage following spinal cord injury (SCI). A potent anti-inflammatory glucocorticoid, methylprednisolone (MP), is the only currently accepted therapy for acute SCI but its efficacy has been questioned. To search for additional anti-inflammatory compounds, we combined microarray analysis with an explanted spinal cord slice culture injury model. We compared gene expression profiles after treatment with MP, acetaminophen, indomethacin, NS398, an  ...[more]

Similar Datasets

2008-04-29 | E-GEOD-9457 | ArrayExpress
2010-06-25 | E-GEOD-13219 | ArrayExpress
2010-06-24 | E-GEOD-14565 | ArrayExpress
2010-07-16 | E-GEOD-22675 | ArrayExpress
2010-06-25 | E-GEOD-6314 | ArrayExpress
2010-06-05 | E-GEOD-1808 | ArrayExpress
2008-10-03 | E-GEOD-12822 | ArrayExpress
2015-05-01 | E-GEOD-13232 | ArrayExpress
2010-05-18 | E-GEOD-9165 | ArrayExpress
2008-11-10 | E-GEOD-13533 | ArrayExpress