Dataset Information


Anti-inflammatory compounds in SCI

ABSTRACT: A screen of 5 anti-inflammatory compounds for their effects in explanted, cultured rat spinal cord slices. All injured (explanted) cords are cultured for 4 hrs.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Jonathan Z Pan   Rebecka Jornsten  Ronald Hart  Ronald P Hart 

PROVIDER: E-GEOD-633 | ArrayExpress | 2010-06-05



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Screening anti-inflammatory compounds in injured spinal cord with microarrays: a comparison of bioinformatics analysis approaches.

Pan Jonathan Z JZ   Jörnsten Rebecka R   Hart Ronald P RP  

Physiological genomics 20040413 2

Inflammatory responses contribute to secondary tissue damage following spinal cord injury (SCI). A potent anti-inflammatory glucocorticoid, methylprednisolone (MP), is the only currently accepted therapy for acute SCI but its efficacy has been questioned. To search for additional anti-inflammatory compounds, we combined microarray analysis with an explanted spinal cord slice culture injury model. We compared gene expression profiles after treatment with MP, acetaminophen, indomethacin, NS398, an  ...[more]

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