Transcriptomics,Genomics

Dataset Information

84

Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Ido Amit   

PROVIDER: E-GEOD-63341 | ArrayExpress| 2015-01-02

SECONDARY ACCESSION(S): GSE63341PRJNA267535

REPOSITORIES: GEO, ArrayExpress

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Publications

Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.

Lavin Yonit Y   Winter Deborah D   Blecher-Gonen Ronnie R   David Eyal E   Keren-Shaul Hadas H   Merad Miriam M   Jung Steffen S   Amit Ido I  

Cell 20141201 6


Macrophages are critical for innate immune defense and also control organ homeostasis in a tissue-specific manner. They provide a fitting model to study the impact of ontogeny and microenvironment on chromatin state and whether chromatin modifications contribute to macrophage identity. Here, we profile the dynamics of four histone modifications across seven tissue-resident macrophage populations. We identify 12,743 macrophage-specific enhancers and establish that tissue-resident macrophages have  ...[more]

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