Dataset Information


Muscle - atypical diabetes protein expression

ABSTRACT: Skeletal muscle biopsies from atypical diabetics at presentation and remission. Protein expression determined with antibody arrays

ORGANISM(S): Homo sapiens  

SUBMITTER: Donald B. Thomason   Donald B Thomason  Guillermo E Umpierrez  Aidar R Gosmanov 

PROVIDER: E-GEOD-634 | ArrayExpress | 2010-06-09



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Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.

Gosmanov Aidar R AR   Umpierrez Guillermo E GE   Karabell Ana H AH   Cuervo Ruben R   Thomason Donald B DB  

American journal of physiology. Endocrinology and metabolism 20040309 1

Although a pharmacological dose of insulin produces a dramatic increase in phosphorylation and activity of Akt isoforms 1 and 2 in mammalian skeletal muscle, few studies have examined the effect of physiological concentrations of insulin on the phosphorylation of Akt-1 and -2 in normal and diabetic tissue. This study examined the patterns of insulin-stimulated Akt isoform phosphorylation and protein expression in muscle biopsies obtained from obese patients with atypical diabetes immediately aft  ...[more]

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