Dataset Information


Statin-induced transcriptional changes in breast cancer

ABSTRACT: Global gene expression profiling was performed on paired tumor biopsies collected before and after 2 weeks of statin treatment with the aim of detecting statin induced changes on tumoral gene expression. In this phase II clinical study using the “window-of-opportunity” design, in which the treatment-free window between a cancer diagnosis and surgical tumor resection is used to study the biological effects of a certain drug, atorvastatin, a lipophilic statin, was prescribed to patients with primary breast cancer for two weeks pre-operatively. Tumor samples subjected to whole genome transcriptional profiling were collected before patients started treatment and after completing treatment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Siker Kimbung   Signe Borgquist 

PROVIDER: E-GEOD-63427 | ArrayExpress | 2015-06-23



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Global Transcriptional Changes Following Statin Treatment in Breast Cancer.

Bjarnadottir Olöf O   Kimbung Siker S   Johansson Ida I   Veerla Srinivas S   Jönsson Mats M   Bendahl Pär-Ola PO   Grabau Dorthe D   Hedenfalk Ingrid I   Borgquist Signe S  

Clinical cancer research : an official journal of the American Association for Cancer Research 20150403 15

Statins purportedly exert antitumoral effects, but the underlying mechanisms are currently not fully elucidated. The aim of this study was to explore potential statin-induced effects on global gene expression profiles in primary breast cancer.This window-of-opportunity phase II trial enrolled 50 newly diagnosed breast cancer patients prescribed atorvastatin (80 mg/day) for 2 weeks presurgically. Pre- and posttreatment tumor samples were analyzed using Significance Analysis of Microarrays (SAM) t  ...[more]

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