Transcriptomics

Dataset Information

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Expression data from mouse kidney epithelial cells


ABSTRACT: Fumarate hydratase (FH) is the enzyme in the Krebs cycle, which transforms fumarate to malate. Loss of fumarate hyrdragase leads to hereditary leiomyomatosis and renal cell cancer (HLRCC). The biallelic inactivation has been highly accumulated in FH-deficient cells and is considered a major pro-oncogenic factor for HLRCC tumorigenesis. We used microarrays to understand the global readaptation of cell metabolism of gene expression underlying the truncated Krebs cycle by loss of function of fumarate hydratase. The fumarate hydratase wild type and knock out cells were generated for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus  

SUBMITTER: Christian Frezza   Elaine Mackenzie  Leon zheng 

PROVIDER: E-GEOD-63438 | ArrayExpress | 2014-11-19

SECONDARY ACCESSION(S): GSE63438PRJNA267735

REPOSITORIES: GEO, ArrayExpress

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