Transcriptomics

Dataset Information

62

MiRNA expression of extracellular vesicles


ABSTRACT: To further investigate the molecular mechanisms by which EVs mediated the abnormal localization of tight junction proteins and adherence junction protein, we performed miRNA microarray analysis of extracellular vesicles isolated from breast cancer cells. miRNA expression in extracellular vesicles was collected from MDA-MB-231-D3H1, MDA-MB-231-D3H2LN, BMD2a and BMD2b breast cancer cell lines.

ORGANISM(S): Homo sapiens  

SUBMITTER: Nobuyoshi Kosaka   Naoomi Tominaga 

PROVIDER: E-GEOD-63445 | ArrayExpress | 2015-04-02

SECONDARY ACCESSION(S): GSE63445PRJNA267765

REPOSITORIES: GEO, ArrayExpress

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Publications

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.

Tominaga Naoomi N   Kosaka Nobuyoshi N   Ono Makiko M   Katsuda Takeshi T   Yoshioka Yusuke Y   Tamura Kenji K   Lötvall Jan J   Nakagama Hitoshi H   Ochiya Takahiro T  

Nature communications 20150401


Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood-brain barrier (BBB). However, the molecular mechanism behind the passage through this natural barrier remains unclear. Here we show that cancer-derived extracellular vesicles (EVs), mediators of cell-cell communication via delivery of proteins and microRNAs (miRNAs), trigger the breakdown of BBB. Importantly, miR-181c promotes the destr  ...[more]

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