Dataset Information


MRNA expression of brain endothelial cells

ABSTRACT: To investigate the mRNA expression after extracellular vesicles or miRNA treatement, global gene expression analysis was performed in endothelial cells after the transfection of N.C. or miR-181c and or after the addition of extracellular vesicles from cancer cells. mRNA expression in brain endothelial cells was collected from negative control or miR-181c treatment and or after the addition of extracellular vesicles from MDA-MB-231-D3H1, MDA-MB-231-D3H2LN, BMD2a and BMD2b breast cancer cell lines.

ORGANISM(S): Macaca fascicularis  

SUBMITTER: Nobuyoshi Kosaka   Naoomi Tominaga 

PROVIDER: E-GEOD-63447 | ArrayExpress | 2015-04-02



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Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.

Tominaga Naoomi N   Kosaka Nobuyoshi N   Ono Makiko M   Katsuda Takeshi T   Yoshioka Yusuke Y   Tamura Kenji K   Lötvall Jan J   Nakagama Hitoshi H   Ochiya Takahiro T  

Nature communications 20150401

Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood-brain barrier (BBB). However, the molecular mechanism behind the passage through this natural barrier remains unclear. Here we show that cancer-derived extracellular vesicles (EVs), mediators of cell-cell communication via delivery of proteins and microRNAs (miRNAs), trigger the breakdown of BBB. Importantly, miR-181c promotes the destr  ...[more]

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