Transcriptomics

Dataset Information

0

MiRNA profile of microglial cells under oxygen-glucose deprivation


ABSTRACT: Migroglia cells were exposed to oxygen-glucose deprivation (OGD) for 3 h. The miRNA was isolated and the expression profiles of OGD-activated cells were compared with the profiles of resting cells. Two samples were analysed. miRNAs that were differentially expressed (increased or decreased in expression by ≥1.5-fold) between theOGD-activated and resting cells were identified.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Peng Wang  Li Zhang    

PROVIDER: E-GEOD-63504 | ArrayExpress | 2015-11-23

SECONDARY ACCESSION(S): GSE63504PRJNA268091

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like receptor 4.

Zhang Li L   Li Ya-Jian YJ   Wu Xun-Yi XY   Hong Zhen Z   Wei Wen-Shi WS  

Journal of neurochemistry 20150212 6


Cerebral hypoxia/ischemia rapidly induces inflammation in the brain, which is characterized by microglial activation and the release of inflammatory cytokines. We have previously demonstrated that miR-181c can directly regulate tumor necrosis factor (TNF)-α production post-transcriptionally. Here, we determined that hypoxia up-regulated TLR4 expression but down-regulated miR-181c expression in primary microglia. We also demonstrated that miR-181c suppresses TLR4 by directly binding its 3'-untran  ...[more]

Similar Datasets

| GSE63505 | GEO
2012-07-06 | E-GEOD-39093 | ArrayExpress
2015-11-23 | E-GEOD-63506 | ArrayExpress
2013-07-01 | E-GEOD-41249 | ArrayExpress
2011-06-17 | E-GEOD-27230 | ArrayExpress
2011-06-17 | E-GEOD-27256 | ArrayExpress
2011-06-17 | E-GEOD-27253 | ArrayExpress
2015-04-10 | E-GEOD-60752 | ArrayExpress
| GSE23158 | GEO
| PRJNA127345 | ENA