Transcriptomics

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Expression and Prognostic impact of LncRNAs in AML


ABSTRACT: Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis and cell-cycle. To determine whether lncRNAs are associated with clinical features and recurrent mutations in older patients (aged ≥60 years) with cytogenetically normal (CN) acute myeloid leukemia (AML), we evaluated lncRNA expression in 148 untreated older CN-AML cases using a custom microarray platform. We analyzed 148 older cytogenetically normal(CN)-AML patients samples using a custom microarray platform and describe the expression of lncRNAs among the AML samples.

ORGANISM(S): Homo sapiens  

SUBMITTER: Maria R Baer  James S Blachly   Carlo M. Croce   Ramiro Garzon   Jessica Kohlschmidt   Deedra Nicolet   Bayard L Powell   Jonathan E Kolitz   Pearlly Yan   Guido Marcucci   Ann-Kathrin Eisfeld   Dimitrios Papaioannou   Clara D Bloomfield   Stefano Volinia   Andrew J Carroll   John C Byrd   Michael A Caligiuri   Donna Bucci   Meir Wetzler   Thomas H Carter   Krzysztof Mrózek   Joseph O Moore   William Blum   Richard M Stone    

PROVIDER: E-GEOD-63614 | ArrayExpress | 2014-11-26

SECONDARY ACCESSION(S): GSE63614PRJNA268451

REPOSITORIES: GEO, ArrayExpress

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