Transcriptomics

Dataset Information

2

Expression and Prognostic impact of LncRNAs in AML


ABSTRACT: Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis and cell-cycle. To determine whether lncRNAs are associated with clinical features and recurrent mutations in older patients (aged ≥60 years) with cytogenetically normal (CN) acute myeloid leukemia (AML), we evaluated lncRNA expression in 148 untreated older CN-AML cases using a custom microarray platform. We analyzed 148 older cytogenetically normal(CN)-AML patients samples using a custom microarray platform and describe the expression of lncRNAs among the AML samples.

ORGANISM(S): Homo sapiens  

SUBMITTER: Maria R Baer   James S Blachly  Carlo M. Croce  Ramiro Garzon  Jessica Kohlschmidt  Deedra Nicolet  Bayard L Powell  Jonathan E Kolitz  Pearlly Yan  Guido Marcucci  Ann-Kathrin Eisfeld  Dimitrios Papaioannou  Clara D Bloomfield  Stefano Volinia  Andrew J Carroll  John C Byrd  Michael A Caligiuri  Donna Bucci  Meir Wetzler  Thomas H Carter  Krzysztof Mrózek  Joseph O Moore  William Blum  Richard M Stone 

PROVIDER: E-GEOD-63614 | ArrayExpress | 2014-11-26

SECONDARY ACCESSION(S): GSE63614PRJNA268451

REPOSITORIES: GEO, ArrayExpress

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