Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Alexander Stark Assa Yeroslaviz Daniel Gerlach Bianca Habermann Maria L Spletter Maria Lynn Spletter Frank Schnorrer
PROVIDER: E-GEOD-63707 | ArrayExpress | 2014-12-23
SECONDARY ACCESSION(S): SRP050336GSE63707PRJNA268841
REPOSITORIES: GEO, ArrayExpress, ENA
Spletter Maria L ML Barz Christiane C Yeroslaviz Assa A Schönbauer Cornelia C Ferreira Irene R S IR Sarov Mihail M Gerlach Daniel D Stark Alexander A Habermann Bianca H BH Schnorrer Frank F
EMBO reports 20141222 2
In Drosophila, fibrillar flight muscles (IFMs) enable flight, while tubular muscles mediate other body movements. Here, we use RNA-sequencing and isoform-specific reporters to show that spalt major (salm) determines fibrillar muscle physiology by regulating transcription and alternative splicing of a large set of sarcomeric proteins. We identify the RNA-binding protein Arrest (Aret, Bruno) as downstream of salm. Aret shuttles between the cytoplasm and nuclei and is essential for myofibril matura ...[more]