Genomics

Dataset Information

304

Genome wide binding sites of NF-κB subunits RelA, RelB, p50, and p52 in the Hodgkin lymphoma cell line L1236


ABSTRACT: The malignant cells of Hodgkin's lymphoma are characterized by a constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We carried out genome-wide localization and expression profiling experiments in the Hodgkin lymphoma cell line L1236 for the canonical and non-canonical NF-κB pathway components p65, p50 and p52, RelB, respectively. We found that the single NF-κB subunits bind to overlapping, but distinct cistromes by using consensus motifs of high similarity. ChIP-Seq analysis of 4 NF-κB subunits with 2 biological replicates each

ORGANISM(S): Homo sapiens  

SUBMITTER: Matthias Heinig   Claus Scheidereit  Eva Kärgel  Giannino Patone  Norbert Huebner 

PROVIDER: E-GEOD-63736 | ArrayExpress | 2016-02-18

SECONDARY ACCESSION(S): SRP050375GSE63736PRJNA268947

REPOSITORIES: GEO, ArrayExpress, ENA

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