Transcriptomics

Dataset Information

97

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity


ABSTRACT: Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signaling and type I-IFN signaling. Comparison of transcriptional profiles of native RNASEH2-deficient patient fibroblasts with wild type cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Min A Lee-Kirsch  Martin Reijns   Axel Roers   Stuart Ralston   Kirsten Lüthke   Annegret Kuhn   Katy Astell   Alice Lorenzi   David Morris   Stefanie Kretschmer   Marta Alarcon-Riquelme   Manfred Gahr   Elisabeth Mangold   Manuel Martinez-Bueno   Timothy Vyse   Andreas Dahl   Inga Melchers   Claudia Günther   Andrea Leitch   Claudia Krug   Min Ae Lee-Kirsch   Andrew Jackson   Torsten Witte   Martin Aringer   Karsten Conrad   Dimitra Alexopoulou   Young A Lee   Sarah Koss   Markus Nöthen   Sophia Blum   Anja Bauernfeind   Doryen Bubeck   Franziska Schmidt   Osvaldo Chara   Louise Bicknell   Norbert Hübner   Deborah C Graham   Christine Wolf   John Isaacs   Barbara Kind   Victoria Tüngler   Elizabeth Blackburn   Annette Bley   Georgia Ramantani   Nicole Berndt   Leonore Unger    

PROVIDER: E-GEOD-63755 | ArrayExpress | 2015-01-02

SECONDARY ACCESSION(S): GSE63755SRP050397PRJNA268979

REPOSITORIES: GEO, ArrayExpress, ENA

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