Dataset Information


Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

ABSTRACT: Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signaling and type I-IFN signaling. Comparison of transcriptional profiles of native RNASEH2-deficient patient fibroblasts with wild type cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Min A Lee-Kirsch   Martin Reijns  Axel Roers  Stuart Ralston  Kirsten Lüthke  Annegret Kuhn  Katy Astell  Alice Lorenzi  David Morris  Stefanie Kretschmer  Marta Alarcon-Riquelme  Manfred Gahr  Elisabeth Mangold  Manuel Martinez-Bueno  Timothy Vyse  Andreas Dahl  Inga Melchers  Claudia Günther  Andrea Leitch  Claudia Krug  Min Ae Lee-Kirsch  Andrew Jackson  Torsten Witte  Martin Aringer  Karsten Conrad  Dimitra Alexopoulou  Young A Lee  Sarah Koss  Markus Nöthen  Sophia Blum  Anja Bauernfeind  Doryen Bubeck  Franziska Schmidt  Osvaldo Chara  Louise Bicknell  Norbert Hübner  Deborah C Graham  Christine Wolf  John Isaacs  Barbara Kind  Victoria Tüngler  Elizabeth Blackburn  Annette Bley  Georgia Ramantani  Nicole Berndt  Leonore Unger 

PROVIDER: E-GEOD-63755 | ArrayExpress | 2014-12-15



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