Transcriptomics

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Expression profile of COUP-TFII overexpressing hearts


ABSTRACT: Increased COUP-TFII levels are found in human dilated cardiomyopathy as well as in mouse models that develop cardiomyopathy. COUP-TFII overexpression in adult mouse hearts caused ventricular dilation and compromised cardiac functions. To gain insights on COUP-TFII’s effect in hearts, we identified the molecular profile of COUP-TFII overexpressing hearts through microarray analysis. The result may shred light on molecular mechanisms that mediate development of dilated cardiomyopathy. We utilized a previously established CAG-S-COUP-TFII allele and crossed it with the Myh6-MerCreMer (Myh6-MCM) line to overexpress COUP-TFII specifically in cardiomyocytes at two months of age by administration of tamoxifen. The experimental group has genotype of Myh6-MCM; CAG-S-COUP-TFII while the control group consists of Myh6-MCM mice (Figure 1C). Whole ventricles were harvested 16 days post induction for molecular profiling.

ORGANISM(S): Mus musculus  

SUBMITTER: San-pin Wu   Sophia Y Tsai  Ming-jer Tsai 

PROVIDER: E-GEOD-63759 | ArrayExpress | 2015-07-24

SECONDARY ACCESSION(S): GSE63759PRJNA269017

REPOSITORIES: GEO, ArrayExpress

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