Transcriptomics

Dataset Information

3

Transcription profiling of human right ventricular samples acquired during cardiac surgery


ABSTRACT: Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. Expression profiling revealed three patterns of gene expression: (1) increased expression above control levels within one hour of cardioplegic arrest, with further amplification during early reperfusion; (2) increased expression limited to the reperfusion phase; and (3) reduced expression during reperfusion. Experiment Overall Design: 4 replicates each: Experiment Overall Design: Stage2, End-ischemia Experiment Overall Design: Stage1, Immediately post-cardioplegic arrest Experiment Overall Design: Stage3, After 5 min. Reperfusion

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Sara Arab 

PROVIDER: E-GEOD-6381 | ArrayExpress | 2008-06-14

SECONDARY ACCESSION(S): GSE6381PRJNA99553

REPOSITORIES: GEO, ArrayExpress

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Publications

Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery.

Arab Sara S   Konstantinov Igor E IE   Boscarino Cathy C   Cukerman Eva E   Mori Alessandro A   Li Jia J   Liu Peter P PP   Redington Andrew N AN   Coles John G JG  

The Journal of thoracic and cardiovascular surgery 20070701 1


OBJECTIVE: The effects of cold cardioplegic arrest and reperfusion on human ventricular gene expression are unknown. We tested the hypothesis that intraoperative ischemia-reperfusion under conditions of blood cardioplegic arrest would induce a unique myocardial genomic profile indicative of a cardioprotective response. METHODS: Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. RESULTS: Expression profiling revealed 3 patterns of gene expression  ...[more]

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