Dataset Information


Endogenous DAF-16 genome-wide recruitment under low Insulin signaling condition in Caenorhabditis elegans

ABSTRACT: In order to understand the complexity of gene regulation downstream of IIS, we used anti-DAF-16 antibody, we report the first genome-wide ChIP-sequencing study of endogenous DAF-16 recruitment in daf-2(e1370). We also report the average bin-wise normalized read count of ZFP-1 and DAF-16 on DAF-16 summits ChIP-Seq profile of DAF-16 in mix stage

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Arnab Mukhopadhyay   A Mukhopadhyay  N Kumar 

PROVIDER: E-GEOD-63865 | ArrayExpress | 2016-03-01



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Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans.

Kumar Neeraj N   Jain Vaibhav V   Singh Anupama A   Jagtap Urmila U   Verma Sonia S   Mukhopadhyay Arnab A  

Oncotarget 20151201 39

Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the first recruitment profile of endogenous DAF-16 and show that the response is conserved. DAF-16 predominantly acts as a transcriptional activator and binding within the 0.5 kb promoter-proximal region results in maximum induction of downstream targets that code for proteins inv  ...[more]

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