Transcriptomics

Dataset Information

30

Microarray analyses of ESAM positive cells in the CD34(+) CD38(-) fraction of collagenase-treated bones


ABSTRACT: We previously identified endothelial cell-selective adhesion molecule (ESAM) as a novel functional marker of hematopoietic stem cells (HSCs) in mice. To examine ESAM expression in human, we analyzed diverse HSC sources using flow cytometry. From mononuclear cells of collagenase-treated human hip bones, we obtained two ESAM positive populations in CD34(+) CD38(-) fraction, referred to as ESAM(High) and ESAM(Bright). Then we conducted microarray analyses comparing gene expression signatures between these two populations. Trabecular tissues of the femora were treated with collagenase IV and DNase. Mononuclear cells were collected, and CD34(+) CD38(-) ESAM(High) or ESAM(Bright) cells were sorted.

ORGANISM(S): Homo sapiens  

SUBMITTER: Michiko Ichii  Takafumi Yokota   Tomohiko Ishibashi    

PROVIDER: E-GEOD-63877 | ArrayExpress| 2015-01-02

SECONDARY ACCESSION(S): GSE63877PRJNA269303

REPOSITORIES: GEO, ArrayExpress

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