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Omics score: 3

Microarray analysis of Wild-type vs. Brpf1-deficient P4 mouse brain

ABSTRACT: RNA was isolated from three pairs of wild-type and Brpf1-deficient mouse brains (the dorsal cortex part) at postnatal day 4 for microarray analysis. The cDNA samples were then labeled and mixed for hybridization with one array. The data from three arrays were obtained and used for bioinformatic analysis.

OTHER RELATED OMICS DATASETS IN: PRJNA269383

ORGANISM(S): Mus Musculus

SUBMITTER: Xiang-Jiao Yang Linya You Hong Zhao Jinfeng Zhou Nicholas R Bertos Edwin Wang Morag Park

PROVIDER: E-GEOD-63909 | ArrayExpress | 2015-04-08

SECONDARY ACCESSION(S): GSE63909PRJNA269383

REPOSITORIES: GEO, ArrayExpress

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			Action	DRS
	E-GEOD-63909.additional.1.zip	Other
	E-GEOD-63909.idf.txt	Idf
	E-GEOD-63909.processed.1.zip	Processed
	E-GEOD-63909.raw.1.zip	Raw
	E-GEOD-63909.sdrf.txt	Txt

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Publications

Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.

You Linya L Zou Jinfeng J Zhao Hong H Bertos Nicholas R NR Park Morag M Wang Edwin E Yang Xiang-Jiao XJ

The Journal of biological chemistry 20150107 11

Epigenetic mechanisms are important in different neurological disorders, and one such mechanism is histone acetylation. The multivalent chromatin regulator BRPF1 (bromodomain- and plant homeodomain-linked (PHD) zinc finger-containing protein 1) recognizes different epigenetic marks and activates three histone acetyltransferases, so it is both a reader and a co-writer of the epigenetic language. The three histone acetyltransferases are MOZ, MORF, and HBO1, which are also known as lysine acetyltra ...[more]

PMID: 25568313

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Inhibition of Met results in concomitant inhibition of Akt and STAT3 signaling pathways, while abrogation of negative feedback permits Erk reactivation

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