Transcriptomics

Dataset Information

6

Expression data from the orthotopic tumors of MES-SA


ABSTRACT: The spontaneous pulmonary metastasis model of human uterine sarcoma was established using GFP-expressed MES-SA cells. Several sublines with different metastatic potentials were generated by in vivo passaging. We used microarrays to identify the metastatic-related genes using the orthotopic tumors with different metastatic potentials. Orthotopic transplanted uterine sarcoma were observed after 3 weeks post-transplantation and the xenografted tumor reached about 2000 mm3 in additional 3 weeks. After 6 weeks post-transplantation, the animals were sacrificed under isoflurane anesthesia, and the tumors were resected. The GFP-positive regions were collected using Leica MZ10F fluorescent stereomicroscope. This study compared the gene expression profiling between the orthotopic tumors with high (H)- and low (L)-metastatic potentials.

ORGANISM(S): Homo sapiens  

SUBMITTER: Tetsuya Mizutani   Shin Ishikane  Kaoru Miyamoto  Shinya Kawabe 

PROVIDER: E-GEOD-63937 | ArrayExpress | 2014-12-08

SECONDARY ACCESSION(S): GSE63937PRJNA269568

REPOSITORIES: GEO, ArrayExpress

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