Transcriptomics,Multiomics

Dataset Information

43

Expression data from Fbxl10 overexpressing 3T3-L1 cells


ABSTRACT: Target genes of Fbxl10 during 3T3-L1 adipogenesis was analyzed 3T3-L1 cells overexpressing Fbxl10 using retrovirus system containing LTR promoter were differentiated and RNA was extracted at day 2 of differentiation

ORGANISM(S): Mus musculus  

SUBMITTER: Satoshi Iwasaki  Takeshi Inagaki    

PROVIDER: E-GEOD-64154 | ArrayExpress| 2015-03-06

SECONDARY ACCESSION(S): GSE64154PRJNA270327

REPOSITORIES: GEO, ArrayExpress

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Publications


Polycomb repressive complex 1 (PRC1) plays an essential role in the epigenetic repression of gene expression during development and cellular differentiation via multiple effector mechanisms, including ubiquitination of H2A and chromatin compaction. However, whether it regulates the stepwise progression of adipogenesis is unknown. Here, we show that FBXL10/KDM2B is an anti-adipogenic factor that is up-regulated during the early phase of 3T3-L1 preadipocyte differentiation and in adipose tissue in  ...[more]

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