Dataset Information


Normal counterpart in the identification of a molecular signature for leukemic promyelocytes

ABSTRACT: Gene expression profiles of 8 samples of CD34+derived normal promyelocytes We collected RNA from CD34+cells from healthy blood donors cultured in serum-free medium with G-CSF, IL-3 and GM-CSF

ORGANISM(S): Homo sapiens  

SUBMITTER: Elena Tenedini  Rossella Manfredini   Alexis Grande   Enrico Tagliafico    

PROVIDER: E-GEOD-64282 | ArrayExpress | 2015-01-02



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Identification of a molecular signature for leukemic promyelocytes and their normal counterparts: Focus on DNA repair genes.

Casorelli I   Tenedini E   Tagliafico E   Blasi MF   Giuliani A   Crescenzi M   Pelosi E   Testa U   Peschle C   Mele L   Diverio D   Breccia M   Lo-Coco F   Ferrari S   Bignami M  

Leukemia 20060921 11

Acute promyelocytic leukemia (APL) is a clonal expansion of hematopoietic precursors blocked at the promyelocytic stage. Gene expression profiles of APL cells obtained from 16 patients were compared to eight samples of CD34+-derived normal promyelocytes. Malignant promyelocytes showed widespread changes in transcription in comparison to their normal counterpart and 1020 differentially expressed genes were identified. Discriminating genes include transcriptional regulators (FOS, JUN and HOX genes  ...[more]

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